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The antibody against POC1A was raised in rabbit using the Recombinant Human POC1 centriolar protein homolog A protein (138-407AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against POC1A was raised in rabbit using the Recombinant Human POC1 centriolar protein homolog A protein (138-407AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using POC1A Antibody at dilution of 1:1002
| Cat.No | ADC-17077A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | POC1A |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human POC1 centriolar protein homolog A protein (138-407AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8NBT0 |
Uniprot Id
Q8NBT0
Target Species
Human
Target Name
POC1A
Target Full Name
POC1 centriolar protein homolog A
Target Function
Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation.
Target Involvement
Short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT)
Target Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle pole. Note=Component of both mother and daughter centrioles.
Target Protein Families
WD repeat POC1 family
Target Synonyms
Pix2; POC1 centriolar protein homolog A (Chlamydomonas); POC1 centriolar protein homolog A; Poc1a; POC1A_HUMAN; WD repeat containing protein 51A; WD repeat domain 51A; WD repeat-containing protein 51A
Target Background
POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutations in this gene result in short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT) syndrome.
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