Rabbit anti-Human EHF Polyclonal Antibody

Uniprot Id

Q9NZC4

Target Species

Human

Target Name

EHF

Target Full Name

ETS homologous factor

Target Function

Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.

Target Subcellular Location

Nucleus.

Target Protein Families

ETS family

Target Tissue Specificity

Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, prostate, and lung. Weakly expressed in kidney and colon. Not detected in heart, brain, placenta, liver, skeletal muscle, spleen,

Target Synonyms

EHF; EHF_HUMAN; Epithelium-specific Ets transcription factor 3; ESE-3; ESE3; ESE3 transcription factor; ESE3B; ESEJ; Ets domain transcription factor; ETS domain-containing transcription factor; ETS homologous factor; hEHF

Target Background

This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene.