Rabbit anti-Human ACTL7B Polyclonal Antibody, HRP conjugated

Uniprot Id

Q9Y614

Target Species

Human

Target Name

ACTL7B

Target Full Name

Actin-like protein 7B

Target Subcellular Location

Cytoplasm, cytoskeleton.

Target Protein Families

Actin family

Target Tissue Specificity

Detected only in the testis and, to a lesser extent, in the prostate.

Target Synonyms

ACL7B_HUMAN; Actin like 7 beta; Actin like 7B; Actin like protein 7B; Actin-like protein 7B; Actin-like-7-beta; ACTL7B; MGC151192; MGC151194; OTTHUMP00000021867; OTTMUSP00000007742; RP11-3J11.2; RP23-48F4.1; t actin 1; Tact1

Target Background

The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known.