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The antibody against FBXW2 was raised in rabbit using the Recombinant Human F-box/WD repeat-containing protein 2 protein (72-340AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against FBXW2 was raised in rabbit using the Recombinant Human F-box/WD repeat-containing protein 2 protein (72-340AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using FBXW2 Antibody at dilution of 1:1002
| Cat.No | ADC-17760A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FBXW2 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human F-box/WD repeat-containing protein 2 protein (72-340AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UKT8 |
Uniprot Id
Q9UKT8
Target Species
Human
Target Name
FBXW2
Target Full Name
F-box/WD repeat-containing protein 2
Target Function
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Target Synonyms
F box and WD 40 domain containing protein 2; F box and WD repeat domain containing 2; F box and WD40 domain protein 2; F box/WD repeat containing protein 2; F-box and WD-40 domain-containing protein 2; F-box/WD repeat-containing protein 2; FBW 2; FBW2; FBXW 2; Fbxw2; FBXW2_HUMAN; Fwd2; Md6; Protein MD6
Target Background
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
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