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The antibody against ZNRF3 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase ZNRF3 protein (56-219AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
The antibody against ZNRF3 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase ZNRF3 protein (56-219AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
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| Cat.No | ADC-17787A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZNRF3 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | FITC conjugated |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human E3 ubiquitin-protein ligase ZNRF3 protein (56-219AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9ULT6 |
Uniprot Id
Q9ULT6
Target Species
Human
Target Name
ZNRF3
Target Full Name
E3 ubiquitin-protein ligase ZNRF3
Target Function
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
ZNRF3 family
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
ZNRF3; KIAA1133; RNF203; E3 ubiquitin-protein ligase ZNRF3; EC 2.3.2.27; RING finger protein 203; RING-type E3 ubiquitin transferase ZNRF3; Zinc/RING finger protein 3
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