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The antibody against SPG11 was raised in rabbit using the Recombinant Human Spatacsin protein (2019-2318AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against SPG11 was raised in rabbit using the Recombinant Human Spatacsin protein (2019-2318AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
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Immunofluorescent analysis of HepG2 cells using SPG11 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
| Cat.No | ADC-18842A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SPG11 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Spatacsin protein (2019-2318AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96JI7 |
Uniprot Id
Q96JI7
Target Species
Human
Target Name
SPG11
Target Full Name
Spatacsin
Target Function
May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport.
Target Involvement
Spastic paraplegia 11, autosomal recessive (SPG11); Amyotrophic lateral sclerosis 5, juvenile (ALS5); Charcot-Marie-Tooth disease 2X (CMT2X)
Target Subcellular Location
Cytoplasm, cytosol. Nucleus. Cell projection, axon. Cell projection, dendrite.
Target Tissue Specificity
Expressed in all structures of brain, with a high expression in cerebellum. Expressed in cortical projection neurons.
Target Synonyms
Colorectal carcinoma associated protein; Colorectal carcinoma-associated protein; DKFZp762B1512; FLJ21439; KIAA1840; Spastic paraplegia 11 (autosomal recessive); Spastic paraplegia 11; Spastic paraplegia 11 protein; Spatacsin; SPG 11; Spg11; SPTCS_HUMAN
Target Background
The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene.
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