Rabbit anti-Human MKL1 Polyclonal Antibody

Uniprot Id

Q969V6

Target Species

Human

Target Name

MRTFA

Target Full Name

Myocardin-related transcription factor A

Target Function

Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus.

Target Involvement

A chromosomal aberration involving MKL1 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with RBM15. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Tissue Specificity

Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain. Expressed in peripheral blood mononuclear cells (at protein level).

Target Research Area

Others

Target Synonyms

AI852829; AMKL; AW743281; AW821984; Basic SAP coiled-coil transcription activator; Bsac; KIAA1438; Mal; Megakaryoblastic leukemia 1 protein; Megakaryocytic acute leukemia protein; MKL (megakaryoblastic leukemia)/myocardin like 1; MKL/myocardin like protein 1; MKL/myocardin-like protein 1; Mkl1; MKL1_HUMAN; MRTF A; Mrtf A; MRTF-A; MRTFA; MYOCARDIN RELATED PROTEIN; Myocardin related transcription factor A; Myocardin-related transcription factor A

Target Background

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants.