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The antibody against Cytotoxin 4 was raised in rabbit using the Recombinant Naja atra Cytotoxin 4 protein (22-81AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against Cytotoxin 4 was raised in rabbit using the Recombinant Naja atra Cytotoxin 4 protein (22-81AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-20555A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Cytotoxin 4 |
| Target Synonyms | antibody; Cytotoxin 4 antibody; CTX-4M antibody; CTX4 antibody; Cardiotoxin A4 antibody; CTX A4 antibody; Cardiotoxin analog IV antibody; CTX IV antibody | Form | Liquid |
| Species Reactivity | Naja atra | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Naja atra Cytotoxin 4 protein (22-81AA) | Target Species | Naja atra (Chinese cobra) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P01443 |
Uniprot Id
P01443
Target Species
Naja atra
Target Function
Basic protein that bind to cell membrane and depolarizes cardiomyocytes. This cytotoxin also shows lytic activities, but 2-fold more important than that of CTX-A2. It binds to the integrin alpha-V/beta-3 with a moderate affinity. Inhibits protein kinase C. It may interact with sulfatides in the cell membrane, which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induces mitochondrial swelling and fragmentation.
Target Subcellular Location
Secreted. Target cell membrane.
Target Protein Families
Snake three-finger toxin family, Short-chain subfamily, Type IA cytotoxin sub-subfamily
Target Tissue Specificity
Expressed by the venom gland.
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