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The antibody against Delta-ctenitoxin-Pn1a was raised in rabbit using the Recombinant Phoneutria nigriventer Delta-ctenitoxin-Pn1a protein (35-82AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against Delta-ctenitoxin-Pn1a was raised in rabbit using the Recombinant Phoneutria nigriventer Delta-ctenitoxin-Pn1a protein (35-82AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-20573A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Delta-ctenitoxin-Pn1a |
| Target Synonyms | antibody; Delta-ctenitoxin-Pn1a antibody; Delta-CNTX-Pn1a antibody; Insecticidal neurotoxin Tx4(6-1) antibody; PnTx4(6-1) antibody | Form | Liquid |
| Species Reactivity | Phoneutria nigriventer | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Phoneutria nigriventer Delta-ctenitoxin-Pn1a protein (35-82AA) | Target Species | Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P59368 |
Uniprot Id
P59368
Target Species
Phoneutria nigriventer
Target Function
This neurotoxin binds at site 3 of insect voltage-activated sodium channels (Nav) and prolongs evoked axonal action potentials by a slowing down of sodium current inactivation. The toxin also inhibits glutamate uptake from rat brain synaptosomes. It reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN). In addition, the toxin shows antinociceptive effect in all rat pain models tested (inflammatory, neuropathic and nociceptive). The antinociceptive effect is partially blocked when selective antagonists of both mu- and delta-opioid receptors are administered, revealing that the antinociceptive effect of the toxin involves both opiod and cannabinoid endogenous systems. In vivo, it is highly toxic to house fly (Musca domestica), toxic to cockroach, but has no effect when intracerebroventricularly injected into mice.
Target Subcellular Location
Secreted.
Target Protein Families
Spider toxin Tx2 family
Target Tissue Specificity
Expressed by the venom gland.
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