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The antibody against LSM1 was raised in rabbit using the Recombinant Human U6 snRNA-associated Sm-like protein LSm1 protein (1-133AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against LSM1 was raised in rabbit using the Recombinant Human U6 snRNA-associated Sm-like protein LSm1 protein (1-133AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human brain tissue using LSM1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human prostate tissue using LSM1 Antibody at dilution of 1:1002
| Cat.No | ADC-21903A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LSM1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human U6 snRNA-associated Sm-like protein LSm1 protein (1-133AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O15116 |
Uniprot Id
O15116
Target Species
Human
Target Name
LSM1
Target Full Name
U6 snRNA-associated Sm-like protein LSm1
Target Function
Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.
Target Subcellular Location
Cytoplasm. Cytoplasm, P-body.
Target Protein Families
SnRNP Sm proteins family
Target Synonyms
Cancer associated Sm like protein; Cancer associated Sm-like; Cancer-associated Sm-like; CASM; lsm1; LSM1; LSM1 homolog; U6 small nuclear RNA associated (S. cerevisiae); Lsm1 protein; LSM1; U6 small nuclear RNA associated; LSM1_HUMAN; Small nuclear ribonuclear CaSm; U6 snRNA associated Sm-like protein LSm1; U6 snRNA-associated Sm-like protein LSm1; YJL124C
Target Background
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
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