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The antibody against QTRT1 was raised in rabbit using the Recombinant Human Queuine tRNA-ribosyltransferase catalytic subunit 1 protein (211-403AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against QTRT1 was raised in rabbit using the Recombinant Human Queuine tRNA-ribosyltransferase catalytic subunit 1 protein (211-403AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-23740A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | QTRT1 |
| Target Synonyms | 43 KD subunit antibody; TGT, catalytic subunit antibody; TGT_HUMAN antibody; TGUT antibody; tRNA guanine transglycosylase antibody; tRNA-guanine transglycosylase antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Queuine tRNA-ribosyltransferase catalytic subunit 1 protein (211-403AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BXR0 |
Uniprot Id
Q9BXR0
Target Species
Human
Target Name
QTRT1
Target Full Name
Queuine tRNA-ribosyltransferase catalytic subunit 1
Target Function
Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
Target Subcellular Location
Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families
Queuine tRNA-ribosyltransferase family
Target Synonyms
FP3235; Guanine insertion enzyme; qtrt1; Queuine tRNA ribosyltransferase 1; Queuine tRNA ribosyltransferase; Queuine tRNA-ribosyltransferase; TGT; TGT, 43 KD subunit; TGT, catalytic subunit; TGT_HUMAN; TGUT; tRNA guanine transglycosylase; tRNA-guanine transglycosylase
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