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The antibody against MICAL2 was raised in rabbit using the Recombinant Human [F-actin]-monooxygenase MICAL2 protein (1-495AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against MICAL2 was raised in rabbit using the Recombinant Human [F-actin]-monooxygenase MICAL2 protein (1-495AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human pancreatic cancer using MICAL2 Antibody at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using MICAL2 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-24434A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MICAL2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human [F-actin]-monooxygenase MICAL2 protein (1-495AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O94851 |
Uniprot Id
O94851
Target Species
Human
Target Name
MICAL2
Target Full Name
[F-actin]-monooxygenase MICAL2
Target Function
Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.
Target Subcellular Location
Nucleus.
Target Protein Families
Mical family
Target Research Area
Cell Biology
Target Synonyms
MICAL2; KIAA0750; MICAL2PV1; MICAL2PV2; [F-actin]-monooxygenase MICAL2; EC 1.14.13.225; Molecule interacting with CasL protein 2; MICAL-2
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