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The antibody against ETHE1 was raised in rabbit using the Recombinant Human Persulfide dioxygenase ETHE1, mitochondrial protein (8-254AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against ETHE1 was raised in rabbit using the Recombinant Human Persulfide dioxygenase ETHE1, mitochondrial protein (8-254AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-24965A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ETHE1 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Persulfide dioxygenase ETHE1, mitochondrial protein (8-254AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O95571 |
Uniprot Id
O95571
Target Species
Human
Target Name
ETHE1
Target Full Name
Persulfide dioxygenase ETHE1, mitochondrial
Target Function
Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus.
Target Involvement
Ethylmalonic encephalopathy (EE)
Target Subcellular Location
Cytoplasm. Nucleus. Mitochondrion matrix.
Target Protein Families
Metallo-beta-lactamase superfamily, Glyoxalase II family
Target Tissue Specificity
Ubiquitously expressed.
Target Research Area
Cell Biology
Target Synonyms
Ethe1; ETHE1 protein; mitochondrial precursor; ETHE1_HUMAN; ethylmalonic encephalopathy 1; Ethylmalonic encephalopathy protein 1; hepatoma subtracted clone one; Hepatoma subtracted clone one protein; HSCO; mitochondrial; Protein ETHE1; Protein ETHE1 mitochondrial; YF13H12
Target Background
This gene encodes a member of the metallo beta-lactamase family of iron-containing proteins involved in the mitochondrial sulfide oxidation pathway. The encoded protein catalyzes the oxidation of a persulfide substrate to sulfite. Certain mutations in this gene cause ethylmalonic encephalopathy, an infantile metabolic disorder affecting the brain, gastrointestinal tract and peripheral vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.
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