Rabbit anti-Human ELAVL2 Polyclonal Antibody

Uniprot Id

Q12926

Target Species

Human

Target Name

ELAVL2

Target Full Name

ELAV-like protein 2

Target Function

RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs. Seems to recognize a GAAA motif. Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR.

Target Protein Families

RRM elav family

Target Tissue Specificity

Brain; neural-specific.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

ELAV like neuron specific RNA binding protein 2; ELAV like Neuronal Protein 1; ELAV like Protein 2; ELAV-like neuronal protein 1; ELAV-like protein 2; ELAV2_HUMAN; ELAVL2; HEL-N1; HELN1; HU Antigen B; Hu-antigen B; HuB; Nervous System Specific RNA Binding Protein MelN1 ; Nervous system-specific RNA-binding protein Hel-N1

Target Background

In humans, the ELAV like RNA binding protein gene family has four members (ELAVL1-4). ELAVL RNA binding proteins recognize AU-rich elements in the 3' UTRs of gene transcripts and thereby regulate gene expression post-transcriptionally. The protein encoded by this gene binds to several 3' UTRs, including its own and also that of FOS, ID, and POU5F1. This gene encodes ELAVL2 and, like ELAVL3 and ELAVL4, is expressed specifically in neurons and primarily localizes to the cytoplasm. This protein also forms a cytosolic complex with the normally nuclear-localized ELAVL1 protein. Alternative splicing of this gene results in multiple transcript variants encoding distinct protein isoforms.