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The antibody against AMER1 was raised in rabbit using the Synthetic peptide of Human AMER1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against AMER1 was raised in rabbit using the Synthetic peptide of Human AMER1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-26739A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AMER1 |
| Target Synonyms | AMER1 antibody; FAM123B antibody; WTXAPC membrane recruitment protein 1 antibody; Amer1 antibody; Protein FAM123B antibody; Wilms tumor gene on the X chromosome protein antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of Human AMER1 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q5JTC6 |
Uniprot Id
Q5JTC6
Target Species
Human
Target Name
AMER1
Target Full Name
APC membrane recruitment protein 1
Target Function
Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.
Target Involvement
Osteopathia striata with cranial sclerosis (OSCS)
Target Subcellular Location
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Translocates to the cell membrane following binding to PtdIns(4,5)P2.
Target Protein Families
Amer family
Target Tissue Specificity
Detected in fetal and adult kidney, brain and spleen.
Target Synonyms
AMER1; FAM123B; WTXAPC membrane recruitment protein 1; Amer1; Protein FAM123B; Wilms tumor gene on the X chromosome protein
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