Rabbit anti-Human TENM3 Polyclonal Antibody

Uniprot Id

Q9P273

Target Species

Human

Target Name

TENM3

Target Full Name

Teneurin-3

Target Function

Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes.

Target Involvement

Microphthalmia, isolated, with coloboma, 9 (MCOPCB9)

Target Subcellular Location

Cell membrane; Single-pass membrane protein. Cell projection, axon.

Target Protein Families

Tenascin family, Teneurin subfamily

Target Tissue Specificity

Expressed in adult and fetal brain, slightly lower levels in testis and ovary, and intermediate levels in all other peripheral tissues examined. Not expressed in spleen or liver. Expression was high in brain, with highest levels in amygdala and caudate nu

Target Synonyms

FLJ10474; FLJ10886; KIAA1455; odd Oz Ten m homolog 3; odz odd Oz ten m homolog 3 (Drosophila); odz odd Oz ten m homolog 3; ODZ3 like protein; Protein Odd Oz ten m homolog 3; Protein Odd Oz/ten-m homolog 3; Ten 3; Ten M3; Ten-3; Ten-m3; TEN3_HUMAN; Tenascin M3; Tenascin-M3; Teneurin 3; Teneurin transmembrane protein 3; Teneurin-3; Teneurin3; tenm3; TNM3