Rabbit anti-Human AHI1 Polyclonal Antibody

Uniprot Id

Q8N157

Target Species

Human

Target Name

AHI1

Target Full Name

Jouberin

Target Function

Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development.

Target Involvement

Joubert syndrome 3 (JBTS3)

Target Subcellular Location

Cytoplasm, cytoskeleton, cilium basal body. Cell junction, adherens junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.

Target Tissue Specificity

Highly expressed in the most primitive normal hematopoietic cells. Expressed in brain, particularly in neurons that give rise to the crossing axons of the corticospinal tract and superior cerebellar peduncles. Expressed in kidney (renal collecting duct ce

Target Synonyms

Abelson helper integration site 1; Abelson helper integration site 1 protein homolog; Abelson helper integration site; AHI 1; AHI-1; Ahi1; AHI1_HUMAN; Contatins SH3 and WD40 domains; dJ71N10.1; DKFZp686J1653; FLJ14023; FLJ20069; JBTS3; Jouberin; ORF1; OTTHUMP00000017263; OTTHUMP00000017265; OTTHUMP00000234456; OTTHUMP00000234654; OTTHUMP00000234656