Rabbit anti-Human PFN1 Polyclonal Antibody

Uniprot Id

P07737

Target Species

Human

Target Name

PFN1

Target Full Name

Profilin-1

Target Function

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.

Target Involvement

Amyotrophic lateral sclerosis 18 (ALS18)

Target Subcellular Location

Cytoplasm, cytoskeleton.

Target Protein Families

Profilin family

Target Tissue Specificity

Expressed in epididymis (at protein level).

Target Research Area

Neuroscience

Target Synonyms

Actin binding protein ; ALS18; Epididymis tissue protein Li 184a; OTTHUMP00000125244; PFN 1; Pfn; PFN1; PROF1_HUMAN; Profilin I; Profilin-1; Profilin1; ProfilinI

Target Background

This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1.