Rabbit anti-Human MYH7 Polyclonal Antibody

Uniprot Id

P12883

Target Species

Human

Target Name

MYH7

Target Full Name

Myosin-7

Target Function

Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.

Target Involvement

Cardiomyopathy, familial hypertrophic 1 (CMH1); Myopathy, myosin storage, autosomal dominant (MSMA); Scapuloperoneal myopathy MYH7-related (SPMM); Cardiomyopathy, dilated 1S (CMD1S); Myopathy, distal, 1 (MPD1); Myopathy, myosin storage, autosomal recessive (MSMB); Left ventricular non-compaction 5 (LVNC5)

Target Subcellular Location

Cytoplasm, myofibril. Cytoplasm, myofibril, sarcomere.

Target Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Myosin family

Target Tissue Specificity

Both wild type and variant Gln-403 are detected in skeletal muscle (at protein level).

Target Research Area

Signal Transduction

Target Synonyms

Beta myosin heavy chain; cardiac muscle beta isoform; CMD1S; CMH1; MPD1; MYH7; MYH7_HUMAN; Myhc slow; MyHC-beta; MyHC-slow; MYHCB; Myopathy, distal 1; Myosin heavy chain (AA 1-96); Myosin heavy chain 7; Myosin heavy chain; Myosin heavy chain slow isoform; Myosin heavy chain, cardiac muscle beta isoform; Myosin, heavy chain 7, cardiac muscle, beta; Myosin, heavy polypeptide 7, cardiac muscle, beta; Myosin-7; Rhabdomyosarcoma antigen MU RMS 40.7A; SPMD; SPMM

Target Background

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing distal myopathy.