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The antibody against PDE10A was raised in rabbit using the Synthesized peptide derived from the N-terminal region of Human PDE10A. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against PDE10A was raised in rabbit using the Synthesized peptide derived from the N-terminal region of Human PDE10A. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
$167.00
Western Blot analysis of A549 cells using PDE10A Polyclonal Antibody
| Cat.No | ADC-32739A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PDE10A |
| Form | Liquid | Species Reactivity | Human, Rat |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the N-terminal region of Human PDE10A. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y233 |
Uniprot Id
Q9Y233
Target Species
Human
Target Name
PDE10A
Target Full Name
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Target Function
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.
Target Involvement
Dyskinesia, limb and orofacial, infantile-onset (IOLOD); Striatal degeneration, autosomal dominant 2 (ADSD2)
Target Subcellular Location
Cytoplasm. Note=Located mostly to soluble cellular fractions.
Target Protein Families
Cyclic nucleotide phosphodiesterase family
Target Tissue Specificity
Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
Target Synonyms
ADSD2; IOLOD; HSPDE10A; PDE10A19; LINC00473; PDE10A
Target Background
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.
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