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The antibody against MAX was raised in rabbit using the Synthesized peptide derived from Human Max around the phosphorylation site of S2. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, ELISA.
The antibody against MAX was raised in rabbit using the Synthesized peptide derived from Human Max around the phosphorylation site of S2. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, ELISA.
$167.00
| Cat.No | ADC-35076A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MAX |
| Target Synonyms | MAX antibody; BHLHD4Protein max antibody; Class D basic helix-loop-helix protein 4 antibody; bHLHd4 antibody; Myc-associated factor X antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from Human Max around the phosphorylation site of S2. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P61244 |
Uniprot Id
P61244
Target Species
Human
Target Name
MAX
Target Full Name
Protein max
Target Function
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.
Target Involvement
Pheochromocytoma (PCC)
Target Subcellular Location
Nucleus. Cell projection, dendrite.
Target Protein Families
MAX family
Target Tissue Specificity
High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
MAX; BHLHD4Protein max; Class D basic helix-loop-helix protein 4; bHLHd4; Myc-associated factor X
Target Background
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants.
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