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The antibody against PACS1 was raised in rabbit using the Recombinant Human Phosphofurin acidic cluster sorting protein 1 protein (757-905AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against PACS1 was raised in rabbit using the Recombinant Human Phosphofurin acidic cluster sorting protein 1 protein (757-905AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-04276A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PACS1 |
| Target Synonyms | Cytosolic sorting protein PACS1 antibody; PACS 1 antibody; PACS-1 antibody; Pacs1 antibody; PACS1_HUMAN antibody; Phosphofurin acidic cluster sorting protein 1 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Phosphofurin acidic cluster sorting protein 1 protein (757-905AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6VY07 |
Uniprot Id
Q6VY07
Target Species
Human
Target Name
PACS1
Target Full Name
Phosphofurin acidic cluster sorting protein 1
Target Function
Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.
Target Involvement
Schuurs-Hoeijmakers syndrome (SHMS)
Target Subcellular Location
Golgi apparatus, trans-Golgi network.
Target Protein Families
PACS family
Target Synonyms
Cytosolic sorting protein PACS1; PACS 1; PACS-1; Pacs1; PACS1_HUMAN; Phosphofurin acidic cluster sorting protein 1
Target Background
This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.
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