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The antibody against ATN1 was raised in rabbit using the Synthesized peptide derived from the N-terminal region of Human Atrophin-1. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against ATN1 was raised in rabbit using the Synthesized peptide derived from the N-terminal region of Human Atrophin-1. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
$167.00
Western Blot analysis of NIH-3T3 cells using Atrophin-1 Polyclonal Antibody
| Cat.No | ADC-39260A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ATN1 |
| Target Synonyms | ATN1 antibody; D12S755E antibody; DRPLAAtrophin-1 antibody; Dentatorubral-pallidoluysian atrophy protein antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the N-terminal region of Human Atrophin-1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P54259 |
Uniprot Id
P54259
Target Species
Human
Target Name
ATN1
Target Full Name
Atrophin-1
Target Function
Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats.
Target Involvement
Dentatorubral-pallidoluysian atrophy (DRPLA)
Target Subcellular Location
Nucleus. Cytoplasm, perinuclear region. Cell junction.
Target Tissue Specificity
Widely expressed in various tissues including heart, lung, kidney, ovary, testis, prostate, placenta, skeletal Low levels in the liver, thymus and leukocytes. In the adult brain, broadly expressed in amygdala, caudate nucleus, corpus callosum, hippocampus
Target Synonyms
ATN1; D12S755E; DRPLAAtrophin-1; Dentatorubral-pallidoluysian atrophy protein
Target Background
Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-35 copies to 49-93 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein.
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