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The antibody against TCTN2 was raised in rabbit using the Recombinant Human Tectonic-2 protein (420-670AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against TCTN2 was raised in rabbit using the Recombinant Human Tectonic-2 protein (420-670AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human skin tissue using TCTN2 Antibody at dilution of 1:100
| Cat.No | ADC-40058A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TCTN2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Tectonic-2 protein (420-670AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96GX1 |
Uniprot Id
Q96GX1
Target Species
Human
Target Name
TCTN2
Target Full Name
Tectonic-2
Target Function
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction.
Target Involvement
Meckel syndrome 8 (MKS8); Joubert syndrome 24 (JBTS24)
Target Subcellular Location
Membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton, cilium basal body.
Target Protein Families
Tectonic family
Target Synonyms
C12orf38; FLJ12975; MKS8; OTTHUMP00000239215; OTTHUMP00000239216; Tctn2; TECT2; TECT2_HUMAN; Tectonic family member 2; Tectonic-2
Target Background
This gene encodes a type I membrane protein that belongs to the tectonic family. Studies in mice suggest that this protein may be involved in hedgehog signaling, and essential for ciliogenesis. Mutations in this gene are associated with Meckel syndrome type 8. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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