Rabbit anti-Human TSEN2 Polyclonal Antibody

Uniprot Id

Q8NCE0

Target Species

Human

Target Name

TSEN2

Target Full Name

tRNA-splicing endonuclease subunit Sen2

Target Function

Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.

Target Involvement

Pontocerebellar hypoplasia 2B (PCH2B)

Target Subcellular Location

Nucleus. Nucleus, nucleolus. Note=May be transiently localized in the nucleolus.

Target Protein Families

TRNA-intron endonuclease family

Target Tissue Specificity

Isoform 1 and isoform 2 are widely expressed at very low level.

Target Synonyms

HsSen2; MGC2776; MGC4440; SEN2; SEN2_HUMAN; SEN2L ; tRNA intron endonuclease Sen2; tRNA splicing endonuclease 2 homolog (SEN2; S. cerevisiae); tRNA splicing endonuclease subunit Sen2; tRNA-intron endonuclease sen2; tRNA-splicing endonuclease subunit Sen2; TSEN 2; TSEN2

Target Background

This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.