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The antibody against MAD2L1BP was raised in rabbit using the Synthesized peptide derived from N-terminal of Human MAD2L1BP. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
The antibody against MAD2L1BP was raised in rabbit using the Synthesized peptide derived from N-terminal of Human MAD2L1BP. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
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Western blot analysis of extracts from K562 cells, using MAD2L1BP antibody.
| Cat.No | ADC-41155A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MAD2L1BP |
| Form | Liquid | Species Reactivity | Human |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from N-terminal of Human MAD2L1BP. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q15013 |
Uniprot Id
Q15013
Target Species
Human
Target Name
MAD2L1BP
Target Full Name
MAD2L1-binding protein
Target Function
May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.
Target Subcellular Location
Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle.
Target Protein Families
MAD2L1BP family
Target Synonyms
Caught by MAD2 protein; CMT2; dJ261G23.1 ; KIAA0110; MAD2L1 binding protein; MAD2L1 binding protein isoform 2; MAD2L1-binding protein; Mad2l1bp; MD2BP_HUMAN; MGC11282; OTTHUMP00000016496; RP1 261G23.6
Target Background
The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
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