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The antibody against CYP2U1 was raised in rabbit using the Synthesized peptide derived from internal of Human Cytochrome P450 2U1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
The antibody against CYP2U1 was raised in rabbit using the Synthesized peptide derived from internal of Human Cytochrome P450 2U1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
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Western blot analysis of extracts from HeLa cells and Lovo cells, using Cytochrome P450 2U1 antibody.
| Cat.No | ADC-41648A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CYP2U1 |
| Target Synonyms | CYP2U1; Cytochrome P450 2U1; Long-chain fatty acid omega-monooxygenase | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human Cytochrome P450 2U1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q7Z449 |
Uniprot Id
Q7Z449
Target Species
Human
Target Name
CYP2U1
Target Full Name
Cytochrome P450 2U1
Target Function
A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May downregulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin.
Target Involvement
Spastic paraplegia 56, autosomal recessive (SPG56)
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein.
Target Protein Families
Cytochrome P450 family
Target Tissue Specificity
Widely expressed with stronger expression in thymus, heart and cerebellum.
Target Synonyms
CYP2U1; Cytochrome P450 2U1; Long-chain fatty acid omega-monooxygenase
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