Rabbit anti-Human EGR1/EGR2 Polyclonal Antibody

Uniprot Id

P18146

Target Species

Human

Target Name

EGR1

Target Full Name

Early growth response protein 1

Target Function

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary. Regulates the amplitude of the expression rhythms of clock genes: ARNTL/BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene ARNTL/BMAL1 in the suprachiasmatic nucleus (SCN).

Target Subcellular Location

Nucleus. Cytoplasm.

Target Protein Families

EGR C2H2-type zinc-finger protein family

Target Tissue Specificity

Detected in neutrophils (at protein level).

Target Research Area

Transcription

Target Synonyms

AT225; Early growth response 1; Early growth response protein 1; EGR 1; EGR-1; EGR1; EGR1_HUMAN; G0S30; KROX 24; KROX24; Nerve growth factor-induced clone A; Nerve growth factor-induced protein A; NGFI-A; NGFIA; TIS8; Transcription factor ETR103; Transcription factor Zif268; ZIF 268; ZIF268; Zinc finger protein 225; Zinc finger protein Krox-24; ZNF225

Target Background

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene.