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The antibody against KDM4B was raised in rabbit using the Synthesized peptide derived from C-terminal of Human JHD3B. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, IHC.
The antibody against KDM4B was raised in rabbit using the Synthesized peptide derived from C-terminal of Human JHD3B. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, IHC.
$297.00
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using JHD3B antibody.
| Cat.No | ADC-42196A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KDM4B |
| Form | Liquid | Species Reactivity | Human |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from C-terminal of Human JHD3B. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O94953 |
Uniprot Id
O94953
Target Species
Human
Target Name
KDM4B
Target Full Name
Lysine-specific demethylase 4B
Target Function
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
Target Subcellular Location
Nucleus.
Target Protein Families
JHDM3 histone demethylase family
Target Synonyms
JHDM3B; JmjC domain-containing histone demethylation protein 3B; JMJD2B; Jumonji domain containing 2B; Jumonji domain containing protein 2B; Jumonji domain-containing protein 2B; Kdm4b; KDM4B_HUMAN; KIAA0876; Lysine (K) specific demethylase 4B; Lysine demethylase 4B; Lysine-specific demethylase 4B; TDRD14B; Tudor domain containing 14B
Target Background
Enables histone H3-methyl-lysine-36 demethylase activity and histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K36 demethylation and histone H3-K9 demethylation. Located in cytosol and nucleoplasm. Implicated in autosomal dominant non-syndromic intellectual disability; breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach cancer. Biomarker of several diseases, including alopecia areata; lung cancer; medulloblastoma; prostate cancer; and stomach cancer.
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