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Rabbit anti-Human AKAP10 Polyclonal Antibody

The antibody against AKAP10 was raised in rabbit using the Synthesized peptide derived from Internal of Human AKAP10. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.

ADC-42228A

The antibody against AKAP10 was raised in rabbit using the Synthesized peptide derived from Internal of Human AKAP10. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.

$297.00

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Specifications


Cat.No ADC-42228A ClonalityPolyclonal
Host SpeciesRabbitTarget NameAKAP10
FormLiquidSpecies ReactivityHuman, Mouse, Rat
Storage BufferPH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+)Purification MethodThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ApplicationELISA, WBStorageUpon receipt

Immunogen Information


Immunogen DescriptionSynthesized peptide derived from Internal of Human AKAP10.Target SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDO43572
Background Information
  • Uniprot Id

    O43572

  • Target Species

    Human

  • Target Name

    AKAP10

  • Target Full Name

    A-kinase anchor protein 10, mitochondrial

  • Target Function

    Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.

  • Target Involvement

    Sudden cardiac death (SCD)

  • Target Subcellular Location

    Mitochondrion. Membrane. Cytoplasm. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic.

  • Target Synonyms

    AKAP10A-kinase anchor protein 10; mitochondrial; AKAP-10; Dual specificity A kinase-anchoring protein 2; D-AKAP-2; Protein kinase A-anchoring protein 10; PRKA10

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