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The antibody against FZR1 was raised in rabbit using the Recombinant Human Fizzy-related protein homolog protein (1-493AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
The antibody against FZR1 was raised in rabbit using the Recombinant Human Fizzy-related protein homolog protein (1-493AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
$299.00
| Cat.No | ADC-44097A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FZR1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | FITC conjugated |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Fizzy-related protein homolog protein (1-493AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UM11 |
Uniprot Id
Q9UM11
Target Species
Human
Target Name
FZR1
Target Full Name
Fizzy-related protein homolog
Target Function
Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR).
Target Subcellular Location
[Isoform 2]: Nucleus.; [Isoform 3]: Cytoplasm.
Target Protein Families
WD repeat CDC20/Fizzy family
Target Tissue Specificity
Isoform 2 is expressed at high levels in heart, liver, spleen and some cancer cell lines whereas isoform 3 is expressed only at low levels in these tissues.
Target Research Area
Cell Biology
Target Synonyms
CDC20 like 1b; CDC20 like protein 1; CDC20-like protein 1; CDC20C; CDH1; Cdh1/Hct1 homolog; Fizzy related protein 1; Fizzy related protein; Fizzy related protein homolog; Fizzy-related protein homolog; Fizzy/cell division cycle 20 related 1; FYR; FZR 1; FZR 2; Fzr; FZR_HUMAN; Fzr1; Fzr1 protein; FZR2; HCDH 1; HCDH; hCDH1; KIAA1242
Target Background
Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in anaphase-promoting complex-dependent catabolic process; mitotic G2 DNA damage checkpoint signaling; and positive regulation of protein metabolic process. Located in nuclear membrane and nucleoplasm. Colocalizes with anaphase-promoting complex.
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