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Rabbit anti-Human HOXA9 Polyclonal Antibody

The antibody against HOXA9 was raised in rabbit using the Recombinant Human Homeobox protein Hox-A9 protein (1-190AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC, IF.

ADC-44132A

The antibody against HOXA9 was raised in rabbit using the Recombinant Human Homeobox protein Hox-A9 protein (1-190AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC, IF.

$299.00

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Specifications


Cat.No ADC-44132A ClonalityPolyclonal
Host SpeciesRabbitTarget NameHOXA9
FormLiquidSpecies ReactivityHuman
IsotypeIgGStorage Buffer50% Glycerol, PBS with 0.02% sodium azide, pH7.3.
Purification MethodAntigen affinity purifiedConjugateNon-conjugated
ApplicationELISA, IF, IHCStorageUpon receipt

Immunogen Information


Immunogen DescriptionRecombinant Human Homeobox protein Hox-A9 protein (1-190AA)Target SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDP31269
Background Information
  • Uniprot Id

    P31269

  • Target Species

    Human

  • Target Name

    HOXA9

  • Target Full Name

    Homeobox protein Hox-A9

  • Target Function

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.

  • Target Involvement

    A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98.; DISEASE: Note=A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2.

  • Target Subcellular Location

    Nucleus.

  • Target Protein Families

    Abd-B homeobox family

  • Target Synonyms

    ABD-B; Abd-B; drosophila; homolog of; D6a9; Homeobox 1G; Homeobox A9; Homeobox protein Hox-1.7; Homeobox protein Hox-1G; Homeobox protein Hox-A9; Homeodomain protein HOXA9; Hox-1.7; Hox-1.7; mouse; homolog of; HOX1; Hox1.7; Hox1G; Hox1r5; Hoxa-9; Hoxa7; HOXA9; HOXA9/MSI2 fusion gene; included; HOXA9/NUP98 fusion gene; included; HXA9_HUMAN; MGC1934

  • Target Background

    In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.

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