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The antibody against TTBK2 was raised in rabbit using the Recombinant Human Tau-tubulin kinase 2 protein (1185-1244AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against TTBK2 was raised in rabbit using the Recombinant Human Tau-tubulin kinase 2 protein (1185-1244AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human lung tissue using TTBK2 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using TTBK2 Antibody at dilution of 1:1002
| Cat.No | ADC-44158A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TTBK2 |
| Target Synonyms | TTBK2 antibody; KIAA0847 antibody; Tau-tubulin kinase 2 antibody; EC 2.7.11.1 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Tau-tubulin kinase 2 protein (1185-1244AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6IQ55 |
Uniprot Id
Q6IQ55
Target Species
Human
Target Name
TTBK2
Target Full Name
Tau-tubulin kinase 2
Target Function
Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.
Target Involvement
Spinocerebellar ataxia 11 (SCA11)
Target Subcellular Location
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytosol. Nucleus.
Target Protein Families
Protein kinase superfamily, CK1 Ser/Thr protein kinase family
Target Research Area
Neuroscience
Target Synonyms
TTBK2; KIAA0847; Tau-tubulin kinase 2; EC 2.7.11.1
Target Background
This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem.
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