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The antibody against ELOA was raised in rabbit using the Recombinant Human Elongin-A protein (679-798AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against ELOA was raised in rabbit using the Recombinant Human Elongin-A protein (679-798AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human tonsil tissue using ELOA Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using ELOA Antibody at dilution of 1:1002
| Cat.No | ADC-45207A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ELOA |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Elongin-A protein (679-798AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q14241 |
Uniprot Id
Q14241
Target Species
Human
Target Name
ELOA
Target Full Name
Elongin-A
Target Function
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
Target Subcellular Location
Nucleus.
Target Synonyms
Ela1; Elo A; EloA; ELOA1_HUMAN; Elongin 110 kDa subunit; Elongin-A; ElonginA; RNA polymerase II transcription factor SIII subunit A1; SIII; SIII p110; TCEB 3; Tceb3; TCEB3A; Transcription elongation factor B (SIII) polypeptide 3 (110kD); Transcription elongation factor B (SIII) polypeptide 3; Transcription elongation factor B alpha subunit; Transcription elongation factor B polypeptide 3
Target Background
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
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