Rabbit anti-Human CTNNBL1 Polyclonal Antibody

Uniprot Id

Q8WYA6

Target Species

Human

Target Name

CTNNBL1

Target Full Name

Beta-catenin-like protein 1

Target Function

Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.

Target Subcellular Location

[Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.

Target Tissue Specificity

Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid.

Target Synonyms

5730471K09Rik; Beta catenin like 1; Beta catenin like protein 1; Beta-catenin-like protein 1; C20orf33; Cadherin associated protein; Catenin beta like 1; Chromosome 20 open reading frame 3; CTBL1_HUMAN; CTNN protein; CTNNBL 1; Ctnnbl1; dJ633O20.1; FLJ21108; NAP; Nuclear associated protein; nuclear protein NAP; Nuclear-associated protein; NYD SP19; OTTMUSP00000016933; P14; P14L; PP8304; RP5 1118M15.1; Testis development protein NYD SP19; Testis development protein NYD-SP19

Target Background

The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome.