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Rabbit anti-Human THEMIS2 Polyclonal Antibody

The antibody against THEMIS2 was raised in rabbit using the Human ICB-1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.

ADC-46578A

The antibody against THEMIS2 was raised in rabbit using the Human ICB-1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.

$600.00

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Specifications


Cat.No ADC-46578A ClonalityPolyclonal
Host SpeciesRabbitTarget NameTHEMIS2
FormLiquidSpecies ReactivityHuman
IsotypeIgGStorage Buffer50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide
Purification MethodAntigen affinity purifiedConjugateNon-conjugated
ApplicationELISA, WBStorageUpon receipt

Immunogen Information


Immunogen DescriptionHuman ICB-1Target SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDQ5TEJ8
Background Information
  • Uniprot Id

    Q5TEJ8

  • Target Species

    Human

  • Target Name

    THEMIS2

  • Target Full Name

    Protein THEMIS2

  • Target Function

    May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production. Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways.

  • Target Subcellular Location

    Nucleus. Cytoplasm.

  • Target Protein Families

    Themis family

  • Target Tissue Specificity

    Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1.

  • Target Synonyms

    Basement membrane induced; Chromosome 1 open reading frame 38; ICB 1; ICB1; Induced by contact to basement membrane 1 protein; Protein ICB 1; Protein ICB-1; Protein THEMIS2; THEMIS2; THMS2_HUMAN; Thymocyte expressed molecule involved in selection protein 2; Thymocyte-expressed molecule involved in selection protein 2

  • Target Background

    Predicted to be involved in T cell receptor signaling pathway and regulation of B cell activation. Predicted to be active in cytoplasm and nucleus.

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