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The antibody against TIPIN was raised in rabbit using the Human TIPIN as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against TIPIN was raised in rabbit using the Human TIPIN as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
$600.00
| Cat.No | ADC-46923A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TIPIN |
| Target Synonyms | FLJ20516 antibody; TIMELESS interacting protein antibody; TIMELESS-interacting protein antibody; TIPIN antibody; TIPIN_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Human TIPIN | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BVW5 |
Uniprot Id
Q9BVW5
Target Species
Human
Target Name
TIPIN
Target Full Name
TIMELESS-interacting protein
Target Function
Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
CSM3 family
Target Synonyms
FLJ20516; TIMELESS interacting protein; TIMELESS-interacting protein; TIPIN; TIPIN_HUMAN
Target Background
The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene.
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