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The antibody against SMG5 was raised in rabbit using the Human SMG5 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against SMG5 was raised in rabbit using the Human SMG5 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$600.00
| Cat.No | ADC-47120A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SMG5 |
| Target Synonyms | SMG5 antibody; EST1B antibody; KIAA1089 antibody; Protein SMG5 antibody; EST1-like protein B antibody; LPTS-RP1 antibody; LPTS-interacting protein antibody; SMG-5 homolog antibody; hSMG-5 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Human SMG5 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UPR3 |
Uniprot Id
Q9UPR3
Target Species
Human
Target Name
SMG5
Target Full Name
Nonsense-mediated mRNA decay factor SMG5
Target Function
Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity.
Target Subcellular Location
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Detected in cytoplasmic mRNA decay bodies.
Target Tissue Specificity
Ubiquitous.
Target Synonyms
SMG5; EST1B; KIAA1089; Protein SMG5; EST1-like protein B; LPTS-RP1; LPTS-interacting protein; SMG-5 homolog; hSMG-5
Target Background
SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).
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