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The antibody against PYCR1 was raised in rabbit using the Recombinant Human Pyrroline-5-carboxylate reductase 1, mitochondrial protein (2-319AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against PYCR1 was raised in rabbit using the Recombinant Human Pyrroline-5-carboxylate reductase 1, mitochondrial protein (2-319AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human breast cancer using PYCR1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using PYCR1 Antibody at dilution of 1:1002
| Cat.No | ADC-49481A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PYCR1 |
| Target Synonyms | PYCR1 antibody; Pyrroline-5-carboxylate reductase 1 antibody; mitochondrial antibody; P5C reductase 1 antibody; P5CR 1 antibody; EC 1.5.1.2 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Pyrroline-5-carboxylate reductase 1, mitochondrial protein (2-319AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P32322 |
Uniprot Id
P32322
Target Species
Human
Target Name
PYCR1
Target Full Name
Pyrroline-5-carboxylate reductase 1, mitochondrial
Target Function
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress.
Target Involvement
Cutis laxa, autosomal recessive, 2B (ARCL2B); Cutis laxa, autosomal recessive, 3B (ARCL3B)
Target Subcellular Location
Mitochondrion.
Target Protein Families
Pyrroline-5-carboxylate reductase family
Target Synonyms
PYCR1; Pyrroline-5-carboxylate reductase 1; mitochondrial; P5C reductase 1; P5CR 1; EC 1.5.1.2
Target Background
This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants.
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