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The antibody against HBG1 was raised in rabbit using the Recombinant Human Hemoglobin subunit gamma-1 protein (2-147AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against HBG1 was raised in rabbit using the Recombinant Human Hemoglobin subunit gamma-1 protein (2-147AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human liver tissue using HBG1 Antibody at dilution of 1:100
| Cat.No | ADC-49487A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HBG1 |
| Target Synonyms | HBG1 antibody; PRO2979 antibody; Hemoglobin subunit gamma-1 antibody; Gamma-1-globin antibody; Hb F Agamma antibody; Hemoglobin gamma-1 chain antibody; Hemoglobin gamma-A chain antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Hemoglobin subunit gamma-1 protein (2-147AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P69891 |
Uniprot Id
P69891
Target Species
Human
Target Name
HBG1
Target Full Name
Hemoglobin subunit gamma-1
Target Function
Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
Target Protein Families
Globin family
Target Tissue Specificity
Red blood cells.
Target Research Area
Signal Transduction
Target Synonyms
HBG1; PRO2979; Hemoglobin subunit gamma-1; Gamma-1-globin; Hb F Agamma; Hemoglobin gamma-1 chain; Hemoglobin gamma-A chain
Target Background
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
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