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The antibody against PLXNA1 was raised in rabbit using the Recombinant Human Plexin-A1 protein (32-296AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against PLXNA1 was raised in rabbit using the Recombinant Human Plexin-A1 protein (32-296AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human colon cancer using PLXNA1 Antibody at dilution of 1:20
| Cat.No | ADC-50954A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PLXNA1 |
| Target Synonyms | PLXNA1 antibody; NOV antibody; PLXN1 antibody; Plexin-A1 antibody; Semaphorin receptor NOV antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Plexin-A1 protein (32-296AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UIW2 |
Uniprot Id
Q9UIW2
Target Species
Human
Target Name
PLXNA1
Target Full Name
Plexin-A1
Target Function
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
Plexin family
Target Tissue Specificity
Detected in fetal brain, lung, liver and kidney.
Target Research Area
Neuroscience
Target Synonyms
PLXNA1; NOV; PLXN1; Plexin-A1; Semaphorin receptor NOV
Target Background
Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including generation of neurons; regulation of GTPase activity; and regulation of cell shape. Predicted to act upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching; neuron projection morphogenesis; and regulation of smooth muscle cell migration. Located in cytosol and nucleoplasm.
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