Rabbit anti-Human SIRT5 Polyclonal Antibody

Uniprot Id

Q9NXA8

Target Species

Human

Target Name

SIRT5

Target Full Name

NAD-dependent protein deacylase sirtuin-5, mitochondrial

Target Function

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.

Target Subcellular Location

Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus.; [Isoform 1]: Cytoplasm. Mitochondrion.; [Isoform 2]: Mitochondrion.

Target Protein Families

Sirtuin family, Class III subfamily

Target Tissue Specificity

Widely expressed.

Target Synonyms

NAD dependent deacetylase sirtuin 5 ; NAD dependent lysine demalonylase and desuccinylase sirtuin 5 mitochondrial; NAD dependent protein deacylase sirtuin 5 mitochondrial; NAD-dependent protein deacylase sirtuin-5; mitochondrial; Regulatory protein SIR2 homolog 5; Silent mating type information regulation 2 S.cerevisiae homolog 5; Sir2 like 5 ; SIR2-like protein 5; SIR2L5; SIR5_HUMAN; Sirt5; Sirtuin 5; Sirtuin type 5

Target Background

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.