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Rabbit anti-Human OSTM1 Polyclonal Antibody

The antibody against OSTM1 was raised in rabbit using the Human OSTM1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.

ADC-52471A

The antibody against OSTM1 was raised in rabbit using the Human OSTM1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.

$600.00

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Specifications


Cat.No ADC-52471A ClonalityPolyclonal
Host SpeciesRabbitTarget NameOSTM1
FormLiquidSpecies ReactivityHuman, Mouse, Rat
IsotypeIgGStorage Buffer50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide
Purification MethodAntigen affinity purifiedConjugateNon-conjugated
ApplicationELISA, WBStorageUpon receipt

Immunogen Information


Immunogen DescriptionHuman OSTM1Target SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDQ86WC4
Background Information
  • Uniprot Id

    Q86WC4

  • Target Species

    Human

  • Target Name

    OSTM1

  • Target Full Name

    Osteopetrosis-associated transmembrane protein 1

  • Target Function

    Required for osteoclast and melanocyte maturation and function.

  • Target Involvement

    Osteopetrosis, autosomal recessive 5 (OPTB5)

  • Target Subcellular Location

    Lysosome membrane; Single-pass type I membrane protein. Note=Requires CLCN7 to travel to lysosomes.

  • Target Protein Families

    OSTM1 family

  • Target Synonyms

    Chloride channel 7 beta subunit; GAIP-interacting protein N terminus; GIPN; GL; Grey lethal osteopetrosis; HSPC019; OPTB5; Osteopetrosis-associated transmembrane protein 1; Ostm1; OSTM1_HUMAN; OTTHUMP00000016938; OTTHUMP00000196342

  • Target Background

    This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis.

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