Rabbit anti-Human CRNN Polyclonal Antibody

Uniprot Id

Q9UBG3

Target Species

Human

Target Name

CRNN

Target Full Name

Cornulin

Target Function

Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways.

Target Subcellular Location

Cytoplasm. Note=Does not colocalize with TGM1.

Target Protein Families

S100-fused protein family

Target Tissue Specificity

Expressed in the basal skin layer (at protein level). Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular l

Target Synonyms

53 kDa putative calcium binding protein; 53 kDa putative calcium-binding protein; 53 kDa squamous epithelial induced stress protein; 53 kDa squamous epithelial-induced stress protein; 58 kDa heat shock protein; C1orf10; Chromosome 1 open reading frame 10; Cornulin; CRNN; CRNN_HUMAN; DRC1; PDRC1; SEP53; Squamous epithelial heat shock protein 53; Tumor related protein; Tumor-related protein

Target Background

This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation.