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The antibody against CACNB2 was raised in rabbit using the Recombinant Human Voltage-dependent L-type calcium channel subunit beta-2 protein (490-637AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against CACNB2 was raised in rabbit using the Recombinant Human Voltage-dependent L-type calcium channel subunit beta-2 protein (490-637AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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| Cat.No | ADC-06492A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CACNB2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Voltage-dependent L-type calcium channel subunit beta-2 protein (490-637AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q08289 |
Uniprot Id
Q08289
Target Species
Human
Target Name
CACNB2
Target Full Name
Voltage-dependent L-type calcium channel subunit beta-2
Target Function
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Target Involvement
Brugada syndrome 4 (BRGDA4)
Target Subcellular Location
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families
Calcium channel beta subunit family
Target Tissue Specificity
Expressed in all tissues.
Target Synonyms
CAB2; MYSB; CAVB2; CACNLB2; CACNB2
Target Background
This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described.
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