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The antibody against TRAP1 was raised in rabbit using the Recombinant Human Heat shock protein 75 kDa, mitochondrial protein (60-308AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF, IP.
The antibody against TRAP1 was raised in rabbit using the Recombinant Human Heat shock protein 75 kDa, mitochondrial protein (60-308AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF, IP.
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Immunofluorescent analysis of Hela cells using TRAP1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-54420A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TRAP1 |
| Target Synonyms | Heat shock protein 75 kDa antibody; Heat shock protein 75 kDa | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, WB, IP |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Heat shock protein 75 kDa, mitochondrial protein (60-308AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q12931 |
Uniprot Id
Q12931
Target Species
Human
Target Name
TRAP1
Target Full Name
Heat shock protein 75 kDa, mitochondrial
Target Function
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
Target Subcellular Location
Mitochondrion. Mitochondrion inner membrane. Mitochondrion matrix.
Target Protein Families
Heat shock protein 90 family
Target Tissue Specificity
Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is highly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors.
Target Research Area
Others
Target Synonyms
Heat shock protein 75 kDa; Heat shock protein 75 kDa, mitochondrial; HSP 75; HSP75; HSP90L; mitochondrial; TNF receptor associated protein 1; TNFR-associated protein 1; TRAP-1; Trap1; TRAP1_HUMAN; Tumor necrosis factor type 1 receptor-associated protein
Target Background
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants.
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