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The antibody against ipaB was raised in rabbit using the Recombinant Shigella flexneri Invasin ipaB(ipaB),partial (1-312aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Protein G Purified. This antibody has been validated on ELISA, WB.
The antibody against ipaB was raised in rabbit using the Recombinant Shigella flexneri Invasin ipaB(ipaB),partial (1-312aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Protein G Purified. This antibody has been validated on ELISA, WB.
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Western Blot | Positive WB detected in Recombinant protein | All lanes: IPAB antibody at 1:2000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 40.2 kDa | Observed band size: 43 kDa
| Cat.No | ADC-54719A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ipaB |
| Target Synonyms | Invasin IpaB (62 kDa antigen), ipaB | Form | Liquid |
| Species Reactivity | Shigella flexneri | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Shigella flexneri Invasin ipaB(ipaB),partial (1-312aa) | Target Species | Shigella flexneri |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P18011 |
Uniprot Id
P18011
Target Species
Shigella flexneri
Target Name
IPAB
Target Function
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Forms a pore with IpaC, which is inserted into the host cell membrane through the Mxi/Spa apparatus, during cell contact. This pore probably allows the translocation of IpaA. IpaB has also been found to be necessary and sufficient to activate macrophage apoptosis by binding to interleukin-1 beta converting enzyme (ICE). Has also been shown to be important, along with IpaD, to block or regulate secretion through the Mxi/Spa translocon in the presence or absence of the secretion signal, respectively. Through interaction with host human MAD2L2, constitutively activates the anaphase-promoting complex APC and induces a cell cycle arrest to prevent epithelial renewal in order to promote bacterial colonization.
Target Subcellular Location
Secreted. Host cell membrane; Multi-pass membrane protein. Host nucleus. Note=Secreted through the specialized type-III secretion system Mxi/Spa. Inserted into the host cell membrane. Also secreted into the host cell cytoplasm after the escape of bacteria from phagosome, where it colocalizes with ICE. May localize to host cell nucleus during G2/M phase of the host cell cycle.
Target Protein Families
Invasin protein B family
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