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The antibody against CHIT1 was raised in rabbit using the Recombinant Human Chitotriosidase-1 protein (215-430aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against CHIT1 was raised in rabbit using the Recombinant Human Chitotriosidase-1 protein (215-430aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-55198A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CHIT1 |
| Target Synonyms | CHIT1, Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Chitotriosidase-1 protein (215-430aa) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q13231 |
Uniprot Id
Q13231
Target Species
Human
Target Name
CHIT1
Target Full Name
Chitotriosidase-1
Target Function
Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.
Target Subcellular Location
Secreted. Lysosome. Note=A small proportion is lysosomal.
Target Protein Families
Glycosyl hydrolase 18 family, Chitinase class II subfamily
Target Tissue Specificity
Detected in spleen. Secreted by cultured macrophages.
Target Synonyms
CHI3; CHIT; CHIT1; CHIT1_HUMAN; CHITD; Chitinase 1; Chitinase 1 (chitotriosidase); Chitinase-1; Chitotriosidase; Chitotriosidase-1; EC 3.2.1.14; FLJ00314; MGC125322; Plasma methylumbelliferyl tetra N acetylchitotetraoside hydrolase
Target Background
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.
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