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The recombinant antibody against GSN was produced using a synthesized peptide derived from Human GSN as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, IF, FC.
The recombinant antibody against GSN was produced using a synthesized peptide derived from Human GSN as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, IF, FC.
$350.00
| Cat.No | ADC-56519A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | GSN | Target Synonyms | Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin), GSN |
| Form | Liquid | Species Reactivity | Human |
| Isotype | Rabbit IgG | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline |
| Purification Method | Affinity-chromatography purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, FC | Storage | Upon receipt |
| Immunogen Description | A synthesized peptide derived from Human GSN | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P06396 |
Uniprot Id
P06396
Target Species
Human
Target Name
GSN
Target Full Name
Gelsolin
Target Function
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Target Involvement
Amyloidosis 5 (AMYL5)
Target Subcellular Location
[Isoform 2]: Cytoplasm, cytoskeleton.; [Isoform 1]: Secreted.
Target Protein Families
Villin/gelsolin family
Target Tissue Specificity
Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.
Target Research Area
Signal Transduction
Target Synonyms
Actin depolymerizing factor; Actin-depolymerizing factor; ADF; AGEL; Brevin; DKFZp313L0718; GELS_HUMAN; Gelsolin; Gsn
Target Background
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
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