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The recombinant antibody against ACTR3 was produced using a synthesized peptide derived from human Arp3 as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB.
The recombinant antibody against ACTR3 was produced using a synthesized peptide derived from human Arp3 as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB.
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Western Blot | Positive WB detected in: PC-3 whole cell lysate, K562 whole cell lysate, HL-60 whole cell lysate, A549 whole cell lysate, Mouse Spleen whole cell lysate, Rat Spleen whole cell lysate | All lanes: Arp3 Antibody at 1:1000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 48 kDa | Observed band size: 48 kDa
| Cat.No | ADC-56809A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | ACTR3 | Target Synonyms | Actin-related protein 3 (Actin-like protein 3), ACTR3, ARP3 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | Rabbit IgG | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline |
| Purification Method | Affinity-chromatography purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | A synthesized peptide derived from human Arp3 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P61158 |
Uniprot Id
P61158
Target Species
Human
Target Name
ACTR3
Target Full Name
Actin-related protein 3
Target Function
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis.
Target Subcellular Location
Cytoplasm, cytoskeleton. Cell projection. Nucleus. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (PubMed:19109554).
Target Protein Families
Actin family, ARP3 subfamily
Target Research Area
Immunology
Target Synonyms
ACTR3; ARP3Actin-related protein 3; Actin-like protein 3
Target Background
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene.
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